ROC Analysis of Subcutaneous Adipose Tissue Topography (SAT-Top) in Female Coronary Heart Disease Patients and Healthy Controls

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概要

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• The aim of this study was to investigate whether subcutaneous adipose tissue topography (SAT-Top) is different in female CHD patients (n=26) and healthy controls (n=36) matched to age, body size, weight, and BMI. The thicknesses of SAT layers were measured by LIPOMETER at 15 specified body sites. To calculate the power of the different body sites to discriminate between CHD women and healthy controls, receiver operating characteristic (ROC) curve analysis was performed. For each parameter, sensitivity and specificity were calculated at different cutoff points. CHD women showed a significant decrease to 78.36% (p=0.012) at body site 11-front thigh, 73.10% (p=0.012) at 12-lateral thigh, 72.20% (p=0.009) at 13-rear thigh, 66.43% (p<0.001) at 14-inner thigh, and 49.19% (p<0.001) at 15-calf. The best discriminators analysed by ROC curves between female CHD patients and healthy controls turned out to be calf and inner thigh (optimal cut off values: calf: 3.85 mm and inner thigh: 11.15 mm). Stepwise discriminant analysis identified the body sites calf, lateral chest, and inner thigh as significant. In conclusion, information was obtained on the extent to which SAT thickness at each measured body site is able to discriminate between the two subject groups. The good discrimination results obtained for the present dataset are encouraging enough to recommend applying LIPOMETER SAT-Top measurements in further studies to investigate individual risks for CHD.

• 日本生理人類学会の論文

著者

• Moller Reinhard

  Institute of Physiological Chemistry, Centre of Physiological Medicine, Medical University Graz

• Tafeit Erwin

  Institute of Physiological Chemistry, Centre of Physiological Medicine, Medical University Graz

• Schnedl Wolfgang

  Department Of Internal Medicine Division Of Cardiology University Hospital Graz

• Wallner Sandra

  Institute Of Pathophysiology Center Molecular Medicine Medical University Graz

• Moller Reinhard

  Institute Of Physiological Chemistry Center Of Physiological Medicine Medical University Graz

• Horejsi Renate

  Institute of Physiological Chemistry, Center of Physiological Medicine, Medical University Graz

• Zweiker Robert

  Department of Internal Medicine, Division of Cardiology, University Hospital Graz

• Watzinger Norbert

  Department of Internal Medicine, Division of Cardiology, University Hospital Graz

• Schauenstein Konrad

  Institute of Pathophysiology, Center of Molecular Medicine, Medical University Graz

• Horejsi Renate

  Institute Of Physiological Chemistry Center Of Physiological Medicine Medical University Graz

• Tafeit Erwin

  Institute Of Physiological Chemistry Center Of Physiological Medicine Medical University Graz

• Schauenstein Konrad

  Institute Of Pathophysiology Center Of Molecular Medicine Medical University Graz

• Zweiker Robert

  Department Of Internal Medicine Division Of Cardiology University Hospital Graz

• Watzinger Norbert

  Department Of Internal Medicine Division Of Cardiology University Hospital Graz

関連論文

• Relationships between Body Fat Measured by DXA and Subcutaneous Adipose Tissue Thickness Measured by Lipometer in Adults
• ROC Analysis of Subcutaneous Adipose Tissue Topography (SAT-Top) in Female Coronary Heart Disease Patients and Healthy Controls

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