Propantheline Attenuates the Peripheral Side Effects of Donepezil without Affecting Its Antiamnestic Properties in Cerebral Ischemic Mice
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概要
- 論文の詳細を見る
Cholinergic deficits are found in both vascular dementia and Alzheimer's disease (AD). Cholinesterase inhibition (CHI) is the only strategy that has been proven to have beneficial effects in patients, but may cause a broad spectrum of adverse events such as nausea, vomiting, and diarrhea, etc. To investigate how to attenuate the peripheral side effects of CHI agents without affecting their efficacy, the effects of propantheline bromide (PB) co-administered with donepezil on the gastric emptying (GE), gastrointestinal transit (GIT), brain cholinesterase (ChE) activities, and maze tasks of mice with memory impairment induced by transient ischemia were observed. The results indicated that PB decreased the increase in GE and GIT, but did not change brain acetylcholinesterase (AChE) activity or the latency of escape in cerebral ischemic mice treated with donepezil. These findings suggest that PB is nearly unable to penetrate the blood-brain barrier and could attenuate the peripheral side effects of CHI agents in the peripheral nervous system and without affecting their therapeutic effects in the central nervous system.
- 2008-08-01
著者
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Zhang Ying
Departmanets Of Structural Pathology Institute Of Nephrology Graduate School Of Medical And Dental S
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Zhang Ying
Department Of Pharmacology School Of Pharmacy Yantai University
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Fu Fenghua
Department of Pharmacology, School of Medicine, Shandong University
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Zhu Mei
Department of Pharmacology, School of Pharmacy, Yantai University
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Zhang Xiumei
Department of Pharmacology, School of Medicine, Shandong University
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Zhu Mei
Department Of Pharmacology School Of Pharmacy Yantai University
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Zhang Xiumei
Department Of Pharmacology School Of Medicine Shandong University
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Zhang Xiumei
Department Of Forest Products Faculty Of Agriculture Kyusyu University
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Fu Fenghua
Department Of Pharmacology School Of Medicine Shandong University:department Of Pharmacology School
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