In Vitro and in Vivo Characterization of Alginate-Chitosan-Alginate Artificial Microcapsules for Therapeutic Oral Delivery of Live Bacterial Cells(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)

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概要

• 論文の詳細を見る

• Oral administration of artificial cell microcapsules entrapping live bacterial cells is a promising approach in disease therapy. However, the current technology of microcapsules limits this approach. In this study, alginate-chitosan-alginate(ACA) microcapsules entrapping live bacterial cells wereprepared with the purpose of oral delivery for therapy, and their in vitro and in vivo propertieswere investigated. Genetically engineered Escherichia coll DH5 were used as the model bacterialstrain. ACA microcapsules remained intact and stable in simulated gastrointestinal fluid and theentrapped bacteria cells survived and grew normally. Moreover, ACA microcapsules were morestable than alginate-polylysine-alginate microcapsules in the rat gastrointestinal tract, which wasattributed to the enhanced resistance of the ACA microcapsules to enzymatic digestion. Therefore,these results reinforce the potential of ACA microcapsules for the therapeutic oral delivery of livebacterial cells.

• 公益社団法人日本生物工学会の論文
• 2008-06-25

著者

• WANG Wei

  Laboratory of Animal Reproduction, College of Animal Science and Technology, Nanjing Agricultural Un

• Ma Xiaojun

  Laboratory Of Biomedical Material Engineering Dalian Institute Of Chemical Physics Chinese Academy O

• Yu Weiting

  Laboratory Of Biomedical Material Engineering Dalian Institute Of Chemical Physics Chinese Academy O

• Lin Junzhang

  Laboratory of Biomedical Material Engineering, Dalian Institute of Chemical Physics, Chinese Academy

• Liu Xiudong

  College of Environment and Chemical Engineering, Dalian University

• Xie Hongguo

  Laboratory of Biomedical Material Engineering, Dalian Institute of Chemical Physics, Chinese Academy

• Liu Xiudong

  College Of Environment And Chemical Engineering Dalian University

• Xie Hongguo

  Laboratory Of Biomedical Material Engineering Dalian Institute Of Chemical Physics Chinese Academy O

• Lin Junzhang

  Laboratory Of Biomedical Material Engineering Dalian Institute Of Chemical Physics Chinese Academy O

• Wang Wei

  Laboratory Of Animal Reproduction College Of Animal Science And Technology Nanjing Agricultural Univ

• Wang Wei

  Laboratory Of Biomedical Material Engineering Dalian Institute Of Chemical Physics Chinese Academy O

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• In Vitro and in Vivo Characterization of Alginate-Chitosan-Alginate Artificial Microcapsules for Therapeutic Oral Delivery of Live Bacterial Cells(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)

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