Apolipoprotein A5 Gene IVS3+G476A Allelic Variant Confers Susceptibility for Development of Ischemic Stroke
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概要
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Background T-1131C, T1259C and IVS3+G476A are naturally occurring variants of the apolipoprotein A5 (APOA5) gene and their possible impact on the development of ischemic stroke was investigated in the present study. Methods and Results PCR-RFLP assays were used to determine the distributions of the APOA5 alleles in small-vessel, large-vessel and mixed subgroups of 378 patients and in 131 stroke-free control subjects. Increased triglyceride levels were found in subjects carrying -1131C, 1259C, IVS3+476A alleles in all stroke groups and in the controls. The -1131C and IVS3+476A alleles, but not the T1259C variant, showed significant accumulation in all stroke subgroups. Logistic regression analysis adjusted for age, gender, body mass index, total cholesterol level, ischemic heart disease, hypertension, diabetes mellitus, smoking-and drinking habits revealed that the IVS3+476A allele represents independent susceptibility factor for stroke (odds ratio for small-vessel: 4.748; large-vessel: 3.905; mixed: 2.926; overall: 3.644 at 95%confidence interval; p<0.05), we could also confirm the previously verified pathogenic role of the -1131C variant. Conclusions All of the 3 APOA5 variants are associated with elevated triglycerides, but only the -1131C and the IVS3+476A alleles confer risk for all types of ischemic stroke; such an association could not be detected for the 1259C allele.
- 社団法人日本循環器学会の論文
- 2008-06-20
著者
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Hadarits Ferenc
Central Laboratory Markusovszky County Hospital
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Kisfali Peter
Department of Medical Genetics and Child Development
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Maasz Anita
Department of Medical Genetics and Child Development
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Horvatovich Katalin
Department of Medical Genetics and Child Development
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Melegh Bela
Department of Medical Genetics and Child Development
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Maasz Anita
Department Of Medical Genetics And Child Development University Of Pecs
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Kisfali Peter
Department Of Medical Genetics And Child Development University Of Pecs
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Horvatovich Katalin
Department Of Medical Genetics And Child Development University Of Pecs
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Jaromi Luca
Department of Medical Genetics and Child Development, University of Pecs
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Szolnoki Zoltan
Department of Neurology and Neurophysiology, Pandy Kalman County Hospital
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Csongei Veronika
Department of Medical Genetics and Child Development, University of Pecs
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Safrany Eniko
Department of Medical Genetics and Child Development, University of Pecs
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Sipeky Csilla
Department of Medical Genetics and Child Development, University of Pecs
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Jaromi Luca
Department Of Medical Genetics And Child Development University Of Pecs
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Sipeky Csilla
Department Of Medical Genetics And Child Development University Of Pecs
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Safrany Eniko
Department Of Medical Genetics And Child Development University Of Pecs
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Szolnoki Zoltan
Department Of Neurology And Neurophysiology Pandy Kalman County Hospital
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Melegh Bela
Department Of Medical Genetics And Child Development University Of Pecs
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Csongei Veronika
Department Of Medical Genetics And Child Development University Of Pecs
関連論文
- Apolipoprotein A5 IVS3+476A Allelic Variant Associates With Increased Trigliceride Levels and Confers Risk for Development of Metabolic Syndrome in Hungarians
- Apolipoprotein A5 Gene IVS3+G476A Allelic Variant Confers Susceptibility for Development of Ischemic Stroke
- Analysis of Hungarian patients with Rett syndrome phenotype for MECP2, CDKL5 and FOXG1 gene mutations