Concise Synthesis of Dimemorfan (DF) Starting from 3-Hydroxymorphinan (3-HM)

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概要

• 論文の詳細を見る

• Dimemorfan (DF) has been known to possess neuroprotective properties. While this promising compound deserves further biological evaluation, synthetic methods have not improved since Murakami group unveiled the synthetic efforts in 1972. Herein a succinct synthesis toward DF from commercially available 3-hydroxymorphinan (3-HM) is disclosed. Other morphinan analogs have been effectively prepared by adopting the similar methodology.

• 公益社団法人日本薬学会の論文
• 2008-07-01

著者

• Kim Hyoung-chun

  College Of Pharmacy Kangwon National University

• Kim Hyoung-choon

  韓国

• KIM Jong

  Small Molecule Group, Central Research Institute, Green Cross Corporation

• KIM Jeongmin

  Small Molecule Group, Central Research Institute, Green Cross Corporation

• LEE Jinhwa

  Small Molecule Group, Central Research Institute, Green Cross Corporation

• Lee Jinhwa

  Small Molecule Group Central Research Institute Green Cross Corporation

• Kim Jong

  Small Molecule Group Central Research Institute Green Cross Corporation

関連論文

• Evidence that protease-activated receptor-2 mediates trypsin-induced reversal of stellation in cultured rat astrocytes
• Concise Synthesis of Dimemorfan (DF) Starting from 3-Hydroxymorphinan (3-HM)
• Protection of Apigenin against Kainate-Induced Excitotoxicity by Anti-oxidative Effects

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