PHA刺激リンパ球の絹胞障害能 : 第3報泌尿生殖器系癌患者の細胞性免疫能

概要

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The phytohaemagglutinin (PHA) induced cytotoxicity of peripheral blood lymphocytes of genitourinary cancer patients against HeLa cells was studied using Takasugi-Klein's microcytotoxicity assay method. There was a significant decrease of the PHA induced cytotoxicity compared with normal persons, especially in patients with advanced genitourinary cancers, mostly renal cell carcinomas. As the PHA induced cytotoxicity was periodically studied in the same patients, the resulsts tend to decrease as the cancer progressing. A decrease in the number of peripheral blood lymphocytes of cancer patients was noted, which showed no significant correlation to the cytotoxicity and blastoid transformation of lymphocytes. The high values of E.S.R., α_1-globulin, α_2-globulin and fibrinogen had no correlation to the cytotoxicity and blastoid transformation either. The blastoid transformation of lymphocytes from cancerbearing patients by the stimulation of PHA was reduced and it correlated to the PHA induced cytotoxicity. However, there was no correlation to the number of peripheral blood lymphocytes and ther parameters. The higher ratio of cytotoxicity and blastoid transformation induced by PHA in cancer patients suggested the role of immunobiological activities of lymphocytes.
社団法人日本泌尿器科学会の論文
1978-11-20