犬乳腺ならびに乳腺腫瘍における炭酸脱水酵素の発現(解剖学)
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概要
- 論文の詳細を見る
炭酸脱水酵素(carbonic anhydrase, CA)は亜鉛を含む金属酵素で,哺乳類組織に広く分布し,二酸化炭素の可逆的加水分解によって呼吸,酸塩基平衡,イオン輸送,骨吸収などの生理的調節,さらには腫瘍の発達にも関与している.しかし,乳腺組織におけるCAの発現については報告がない.本研究では,正常乳腺組織ならびに乳腺腫瘍組織両者のCA発現を組織検索とRT-PCRによって検討した.犬の正常乳腺組織と乳腺腫瘍組織において,CA II,IV, VI, IX4種類のCA isoenzyme mRNA発現をRT-PCRレベルで観察すると,両者でバンドパターンが異なっていた. CAII, IV, VI, IX mRNA発現は正常乳腺組織でのみ認められたことから,これらは乳腺組織の生理的状態を維持する上で必須の酵素であると思われた.しかしながら,CA IV発現は悪性乳腺腫瘍に認められなかったことから, CAIVは犬乳腺腫瘍の診断上のマーカーになることを示す.
- 社団法人日本獣医学会の論文
- 2008-05-25
著者
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Kuo Tzong-fu
Department Of Veterinary Medicine College Of Agriculture National Taiwan University
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JEN Yi-Fan
Department of Veterinary Medicine, College of Agriculture, National Chiayi University
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LEE Wei-Ming
Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University
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LIN Cheng-Chung
Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University
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CHENG Yeong-Hsiang
Department of Animal Science, National I-Lan University
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WANG Jiann-Hsiung
Department of Veterinary Medicine, College of Agriculture, National Chiayi University
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CHANG Ming-Huang
Department of Veterinary Medicine, College of Agriculture, National Chiayi University
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Jen Yi-fan
Department Of Veterinary Medicine College Of Agriculture National Chiayi University
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Lee Wei-ming
Department Of Veterinary Medicine College Of Veterinary Medicine National Chung Hsing University
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Lin Cheng-chung
Department Of Veterinary Medicine College Of Veterinary Medicine National Chung Hsing University
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Lin Cheng-chung
Department Of Oral Pathology And Department Of Oral & Maxillofacial Surgery School Of Dentistry
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Wang Jiann-hsiung
Department Of Veterinary Medicine College Of Agriculture National Chiayi University
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Chang Ming-huang
Department Of Veterinary Medicine College Of Agriculture National Chiayi University
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Cheng Yeong-hsiang
Department Of Animal Science National I-lan University
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KUO Tzong-Fu
Department and Graduate Institute of Veterinary Medicine, National Taiwan University
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