Reaction Structure Profile : A Comparative Analysis of Metabolic Pathways Based on Important Substructures

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概要

• 論文の詳細を見る

• Comparative analysis of organisms with metabolic pathways gives important imformation about functions within organisms. In this paper, we propose a new method for comparing the metabolic pathways with reaction structures that include important enzymes. In this method, subgraphs from pathways that include 'choke point' or 'load point' are extracted as important "reaction strucures," and a "reaction structure profile," which represents whether extracted reaction structures are observed in the metabolic pathway of other organisms, is created. Distance regarding function within organisms between species is defined using the "reaction structure profile." By applying the proposed method to the metabolic networks of 64 representative organisms selected from Archaea, Eubacteria and Eukaryote in the KEGG database, we succeed in recnstructing a phylogenetic tree, and confirm the effectiveness of the method.

• 一般社団法人情報処理学会の論文
• 2008-03-15

著者

• Ohkawa Takenao

  Graduate School Of Engineering Kobe University

• Ashida Yuta

  Graduate School Of Engineering Kobe University

• Ozaki Tomonobu

  Organization Of Adavanced Science And Technology Kobe University

関連論文

• A Method to Extract Sentences with Protein Functional Information from Literature by Iterative Learning of the Corpus
• Reaction Structure Profile : A Comparative Analysis of Metabolic Pathways Based on Important Substructures
• Reaction Structure Profile: A Comparative Analysis of Metabolic Pathways Based on Important Substructures
• Selection of Effective Sentences from a Corpus to Improve the Accuracy of Identification of Protein Names

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