Constituents from Clausena excavata
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概要
- 論文の詳細を見る
Three new coumarins containing a C_<10> terpenoid side chain, clauslactones R-T (1-3), together with 14 known coumarins (4-17) and 11 known carbazole alkaloids (18-28), were isolated from the leaves and stems of Clausena excavata. Their structures were established by detailed spectroscopic analyses. Furthermore, the stereochemistry of 1 was confirmed by single-crystal X-ray diffraction analysis, which was the first example among coumarins with a C_<10> terpenoid side chain. Additionally, compounds 22 and 27 were found to show moderate topoisomerase II inhibitory effects at 50μM.
- 社団法人日本薬学会の論文
- 2008-06-01
著者
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Lu Jing-jian
State Key Laboratory Of Drug Research Shanghai Institute Of Materia Medica Chinese Academy Of Scienc
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XIN Zhen-Qiang
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Scie
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KE Chang-Qiang
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Scie
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HU Chao-Xin
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Scie
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LIN Li-Ping
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Scie
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YE Yang
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Scie
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Ye Yang
State Key Laboratory Of Drug Research Shanghai Institute Of Materia Medica Chinese Academy Of Scienc
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Lin Li-ping
State Key Laboratory Of Drug Research Shanghai Institute Of Materia Medica Chinese Academy Of Scienc
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Hu Chao-xin
State Key Laboratory Of Drug Research Shanghai Institute Of Materia Medica Chinese Academy Of Scienc
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Ke Chang-qiang
State Key Laboratory Of Drug Research Shanghai Institute Of Materia Medica Chinese Academy Of Scienc
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Xin Zhen-qiang
State Key Laboratory Of Drug Research Shanghai Institute Of Materia Medica Chinese Academy Of Scienc
関連論文
- Constituents from Clausena excavata
- Potentiation of Adenosine A_1 Receptor Agonist CPA-Induced Antinociception by Paeoniflorin in Mice(Pharmacology)