16 CHEMICAL STRUCTURE AND TOXICITY OF THE POISONOUS COMPONENTS OF THE MUSHROOM AMANITA PHALLOIDES
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概要
- 論文の詳細を見る
The toxic mushroom Amanita phalloides contains 2 classes of lethal toxins, the phallotoxins and the amatoxins. Both of these are cyclic oligopeptides whose ring is divided into two moieties by a sulfur- or a sulfoxide bridge. In the phallotoxin series many chemical manipulations are possible at the periphery or in the centrum without loss of toxicity. A OH-group in γ-position of a side chain is not essential. Fission of only one of the 3 cross linkages, however, removes toxicity. There are some paralleles of ORD curves and toxicity demonstrating the strict dependence of biological action on molecular shape.-In the amatoxin series principally the same applies. Also here the intact shape of the rigid molecule is prerequisite of toxic effect but a OH group in γ-position of a side chain is essential. The amatoxins are strong inhibitory substances of a solubilized DNA dependent RNA polymerase of eukaryotic cells.
- 天然有機化合物討論会の論文
- 1970-10-01
著者
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Wieland Th.
Max Planck Institute For Medical Research Chemistry Department Heidelberg And Institute Of Organic C
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Faulstich H.
Max Planck Institute for Medical Research, Chemistry Department, Heidelberg and Institute of Organic
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Fahrenholz F.
Max Planck Institute for Medical Research, Chemistry Department, Heidelberg and Institute of Organic
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Fahrmeir A.
Max Planck Institute for Medical Research, Chemistry Department, Heidelberg and Institute of Organic
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Fahrmeir A.
Max Planck Institute For Medical Research Chemistry Department Heidelberg And Institute Of Organic C
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Faulstich H.
Max Planck Institute For Medical Research Chemistry Department Heidelberg And Institute Of Organic C
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Fahrenholz F.
Max Planck Institute For Medical Research Chemistry Department Heidelberg And Institute Of Organic C