Biological Effects of a Sulfated-Polysaccharide Isolated from the Marine Red Algae Champia feldmannii(Miscellaneous)

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Sulfated-polysaccharides are exploited as antithrombotic and anticoagulant agents and suggested to be immunostiniulants. The sulfated-polysaccharide isolated from the red-marine-algae Champia feldmannii (Cf-PLS) was purified by ion exchange chromatography and tested in experimental protocols of coagulation, inflammation (in Wistar rats) and nociception (in Swiss mice). Cf-PLS was tested i.v. for its anti-inflammatory activity in the paw-edema induced by classical inflammatory stimuli and s.c. for its pro-inflammatory activity in the pawedema and peritonitis models. The anticoagulant activity was evaluated by the test of partial thromboplastin activation time (aPTT) and the antinociceptive effect in the writhing-test. Cf-PLS was not anti-inflammatory, but rather induced maximal edematogenic activity at 0.9mg/kg (1.01±0.030×0.06±0.03 ml) compared to controls (0.06±0.03 ml), increased vascular-permeability (38.44±12.63×11.29±3.91 μg/g) and stimulated neutrophil migration (3.348±295×307±99 cells/μl) 1h after injection. Cf-PLS was also antinociceptive (6.6±1.28×33±1.44 writhes) and extended human plasma coagulation time by 3 times. Our data suggest that this molecule may be an important immunostimulant.
社団法人日本薬学会の論文
2008-04-01