56 (+)-アフリカノール及びその立体異性体の全合成(ポスター発表の部)

概要

論文の詳細を見る
(+)-Africanol(1), an isoprenoid sesquiterpene alcohol first isolated in 1974 from the soft coral Lemnalia africana. has been synthesized. Key steps for our de novo synthesis are (a) utilization of the diastereodifferentiating double cyclopropanations to dienol ether of optically active 2,5-dimethyl-3,5-heptanediol(DMHD) as a viable means for constructing desired stereocenters and (b) construction of angular hydroxyl five membered ring by reductive cyclization of δ,ε-unsaturated enone. Synthesis of optically active precouser 12 and 2-epimer, 15 had been achieved fully stereocontrolled in 14 and 15 steps. Reductive cyclization of 12 afforded several isomers incruding (+)-1.
天然有機化合物討論会の論文
1990-09-25