21 万両から得られる環状デプシペプチドの構造解析

概要

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The structure of FR900359, a novel cyclic depsipeptide from Ardisia crenata sims that shows inhibition of platelet aggregation and activity to decrease the blood pressure, has been determined as 3-acetamide-22-benzyl-10-[1-(3-hydroxy-4-methyl-2-propionamidopentanoyloxy)-2-methylpropyl]-4-isopropyl-7-(1-methoxyethyl)-19-methylene-8,13,14,16,20-pentamethyl-1,5-dioxa-8,11,14,17,20-pentaazacyclodocosane-2,6,9,12,15,18,21-heptone by ^1H- and ^<13>C-NMR and Mass spectrometry. FR900359 consisted of ten units: alanine, N-methylalanine, β-hydroxyleucine, 3-phenyllactic acid, acetic acid, propionic acid and novel amino acids N-methyldehydroalanine and N,O-dimethylthreonine (1:1:3:1:1:1:1:1, by molar ratio). Of particular significance of this cyclic depsipeptide are the novel amino acid constituents N-methyldehydroalanine and N,O-dimethylthreonine. As far as we know, the former has been known only in a toxin from the blue-green alga, Microcystis aeruginosa, and the latter has not yet been found in nature till now.
天然有機化合物討論会の論文
1986-09-09