82 抗生物質ホーテイマイシンBの全合成
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概要
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Total synthesis of antibiotic fortimicin B (1b) is described. The sugar component of 1b: 6-epi-purpurosamine B was converted to the sugar chloride: 2,6-bis(2,4-dinitrophenylamino)-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl chloride (5). The aminocyclitol component of 1b: fortamine B was also converted to the partially protected aglycone (9). The condensation of the aglycone 9 with the sugar chloride 5 gave the aimed condensation product (20) in 37% yield. The analogous condensation of the DL-form of the aglycone 19 with 5 afforded the same condensation product in 19% yield, which was converted to 1b by stepwise hydrolysis.
- 天然有機化合物討論会の論文
- 1981-09-10