22 12,13-Epoxytrichothec-9-eneの合成

概要

論文の詳細を見る
12,13-Epoxytrichothec-9-ene (2) is a metabolite isolated from Trichothecium roseum by Nozoe et al. and its structure was synthetically confirmed by Tatsuno et al. In this paper we wish to report the first biomimetic synthesis of (2) modelled on the proposed biogenetic scheme. The key intermediate (4) was synthesised by photocyclo-addition followed by acid cleavage. This was transformed into the diene diol (33) which was stereoselectively cyclised to (34) by acid. Epoxydation of (34) gave the title compound.
天然有機化合物討論会の論文
1976-09-20