1 3-ヒドロキシフラボン類の接触酸素酸化 : クエルセチナーゼ反応のモデル

概要

論文の詳細を見る
The oxygenation of 3-hydroxyflavones in DMF in the presence of ButOK resulted in the formation of the corresponding depsides and carbon monoxide in nearly quantitative yield through oxidative cleavage of the heterocyclic ring of 3-hydroxyflavones. The oxidative cleavage of 3-hydroxyflavones was also caused by oxygenation catalyzed with cobalt or copper complexes in DMF. The present results can provide a nonenzymic model for the reaction of quercetinase. The catalytic oxygenation was highly affected by solvent and substitution at 4'-position with OH group, which accelerates the reaction. 3',4'-Dihydroxy groups of quercetin led to the formation of complex mixture in the reaction. A plansible mechanism of the catalytic oxygenation of 3-hydroxyflavones involving radical process will be discussed.
天然有機化合物討論会の論文
1972-10-01