43 スッポン胆汁成分の研究(I) : 新胆汁酸の分離とその構造
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概要
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Isolation and chemical structure of new bile acids from the soft shelled turtle bile were reported in this paper. 1. The bile components were separated by column chromatography according to the method of Bergstrom et al. 2. The bile salts were constituted from 60-70% of conjugate bile acids and 30-40% of free bile acids, respectively. 3. Three kinds of free bile acids, Amydic acid, Deoxyamydic acid and Trionychic acid named by us, were isolated from the bile. 5. Infrared spectrum of Deoxyamydic acid, m.p. 195-198℃ indicated the presece of deoxycholic acid nucleus, and Deoxyamydic lactone 1 (amorphous) was derived from this acid in the same manner as that of Amydic lactone 1. On this bases, the structure of this acid would be 3α, 12α, 22(or 23) ζ-trihydroxycoprostanic acid. 6. Trionychic acid, m.p. 206℃ might have 3α, 12α-dihydroxyl groups and another hydroxyl group in the steroid nucleus also, and further a secondary hydroxyl group at C_<22> or C_<23> position of the side chain. 7. The conjugate bile acids were chiefly taurine conjugate of Amydic acid and Deoxyamydic acid.
- 天然有機化合物討論会の論文
- 1971-10-01