29 簡單な天然有機化合物の簡單な合成
スポンサーリンク
概要
- 論文の詳細を見る
Syntheses of two simple alkaloids of unique structures are described in two separate sections(I and II) I Synthesis of Shihunine(1) Two-step synthesis of shihunine has been achieved. The first step of the synthesis was Claisen condenzation of dimethylphthalate (4) with N-methylpyrrolidone(3) affording 3-(1-methyl-2-oxo-3-pyrrolidinylidene)phthalide(10). Then the ketonic fission of (10) gave shihunine(1), which was identical with the natural alkaloid in all respects. II Synthesis of Withasomnine(17) Three-step biogenetic-type synthesis of withasomnine(17) has been achieved. The first step of the synthesis was alkaline condenzation of benzylcyanide(25) with O-methylpyrrolidone(26), affording 1-(2-pyrrolidinylidene)-1-phenylacetonitril(27). The condenzation product(27) was reduced to assumed biosynthetic intermediate diamine(24), which was, then, cyclized to natural withasomnine(17) by mild oxydation under physiological condition.
- 天然有機化合物討論会の論文
- 1968-09-20