The reduction of arterial tension produced by stevioside is dependent on nitric oxide synthase activity when the endothelium is intact

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概要

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• In endothelium-intact rat aortic ring preparations pre-contracted with norepinephrine or KC1, N^G-nitro L-arginine (L-NOARG, 0.1 mM) and 1H-[1,2,4] oxidiazolo [4,3-a] quinoxalin-1-one (ODQ, 10μM) antagonized the reduction of the vascular tone induced by stevioside, but this antagonism did not occur when the experiment was performed with endothelium-denuded aortic rings. The data indicates that the vasodilatation produced by stevioside is dependent on nitric oxide synthase and guanylate cyclase activities when the endothelium is not damaged.

著者

• Amaral Valeria

  Department Of Pharmacy And Pharmacology State University Of Maringa

• Bornia Elaine

  Department Of Pharmacy And Pharmacology State University Of Maringa

• Bornia Elaine

  Department Of Pharmacology State University Of Maringa

• BAZOTTE Roberto

  Department of Pharmacy and Pharmacology, State University of Maringa

• ALVES-DO-PRADO Wilson

  Department of Pharmacy and Pharmacology, State University of Maringa

• Alves-do-prado Wilson

  Department Of Pharmacology State University Of Maringa

• Alves-do-prado Wilson

  Department Of Pharmacy And Pharmacology State University Of Maringa

• Bazotte Roberto

  Department Of Pharmacy And Pharmacology State University Of Maringa

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