The Stimulatory Activities of Polysaccharide Compounds Derived from Algae Extracts on Insulin Secretion in Vitro(Pharmacognosy)
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概要
- 論文の詳細を見る
We prepared two series of polysaccharide compounds derived from algae extracts and investigated their stimulatory activity on insulin secretion in vitro using the rat pancreatic cell line, RIN-5F. Several of the compounds exhibited significant stimulatory activity in a dose-dependent manner without apparent cytotoxicity at concentrations above 10 μM. Glybenclamide, a commonly prescribed sulfonylurea (SU) against diabetes mellitus type II, was used as a positive control and showed moderate cytotoxicity in the cell culture assay system. Amylin (IAPP; islet amyloid polypeptide), an inhibitor for glybenclamide, did not inhibit the activity of the isolated compounds, suggesting that they act through a mechanism(s) different from glybenclamide. Algae-derived extracts could be candidates for a new class of anti-diabetic drugs.
- 公益社団法人日本薬学会の論文
- 2008-05-01
著者
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Ito Kaori
Laboratory Of Clinical Pharmacology And Therapeutics Faculty Of Pharmaceutical Sciences Sojo Univers
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Matsukura Makoto
Laboratory Of Clinical Pharmacology And Therapeutics Faculty Of Pharmaceutical Sciences Sojo Univers
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Guan Huashi
The Institute Of Marine Drug And Food College Of Medicine And Pharmaceutics Ocean University Of Chin
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Shinohara Makoto
Ashikita Institution For Developmental Disabilities
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Zhang Dandan
The Institute Of Marine Drug And Food College Of Medicine And Pharmaceutics Ocean University Of Chin
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Fujii Isao
Laboratory Of Clinical Pharmacology And Therapeutics Faculty Of Pharmaceutical Sciences Sojo Univers
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Zhao Ji'en
Ashikita Institution For Developmental Disabilities
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LIN Changzheng
The Institute of Marine Drug and Food, College of Medicine and Pharmaceutics, Ocean University of Ch
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Lin Changzheng
The Institute Of Marine Drug And Food College Of Medicine And Pharmaceutics Ocean University Of Chin
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