溶解パラメータ(δ)による化学物質の哺乳動物に対する急性毒性(LD_<50>)の解析 : (2)マウスの急性経口毒性

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Acute oral toxicity (LD_<50>-value) of organic chemicals to mice was analyzed by using solubility parameter (δc), a thermodynamic parameter, of the chemicals. As it was observed in the previous study with rats, parabolic correlations were established between logarithm of LD_<50>-value (mmol/kg body weight, mice) and δc of all the collected chemicals (n=85, R=0.626), alcohols (n=10, R=0.683), ketones (n=7, R=0.631) and aromatics (n=62, R=0.645). Introducing molar volume (Vc) to the above equations did not improve the correlations. Although statistically significant correlations were not found in alcohols and ketones with mice, we successfully assured the theoretical equation regardless of species difference by establishing significant correlations with all the collected chemicals and aromatics. By analysis, we could determine the solubility parameter of 2.27×10^4(J/m^3)^<1/2> for the biological membrane (absorption site) of mice. As the δc-values which dip the LD_<50>-values are approximately the same for mice and rats, common deleterious effects and mechanism may be working at common target sites. In addition, no species difference in sensitivity (toxicity) was found for the aromatics. For comparison, log P was used to describe LD_<50> of all the collected chemicals, but no correlation was established (R=0.004-0.418).
社団法人日本産業衛生学会の論文
1994-11-20