Synthesis of the Key Intermediate, Diethyl 2-Acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the Immunomodulatory Agent FTY720 (Fingolimod)
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概要
- 論文の詳細を見る
The key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate (13), for the immunomodulatory agent FTY720 (2: fingolimod) was synthesized via Michael addition of diethyl(acetylamino)malonate (6) to 4-octanoylstyrene (12).
- 公益社団法人日本薬学会の論文
- 2008-04-01
著者
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FUJITA Tetsuro
Faculty of Pharmaceutical Sciences, Kyoto University
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Hirose Ryoji
Research Laboratory Taito Co. Ltd.
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Sasaki Shigeo
Research Laboratory Taito Co. Ltd.
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Fujita Tetsuro
Faculty Of Pharmaceutical Sciences Setsunan University
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Fujita Tetsuro
Faculty Of Pharmaceutical Sciences Kyoto University
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MATSUMOTO Norimasa
Research Laboratory, Taito Co., Ltd.
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Matsumoto Norimasa
Research Laboratory Taito Co. Ltd.
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Sasaki Shigeo
Research Laboratory Mitsui Sugar Co. Ltd.
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- Synthesis of the Key Intermediate, Diethyl 2-Acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the Immunomodulatory Agent FTY720 (Fingolimod)