Synthesis, Characterization, Antioxidant Activity, and DNA-Binding Studies of 1-Cyclohexyl-3-tosylurea and Its Nd(III), Eu(III) Complexes

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概要

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• A new ligand, 1-cyclohexyl-3-tosylurea (H_2L), was prepared by condensation ethyl N-(3-tossulfonyl) carbamate and cyclohexanamine. Its two lanthanide(III) complexes, Ln(H_2L)_3・3NO_3 [Ln=Nd (1), and Eu (2)], have been synthesized and characterized on the base of element analyses, ESI-MS, molar conductivities, IR spectra and thermogravimetry/differential thermal analysis (TG-DTA). In addition, the DNA-binding properties of the ligand and its complexes have been investigated by electronic absorption spectroscopy, fluorescence spectroscopy, circular dichroic (CD) spectroscopy and viscosity measurements. The experiment results suggest that the ligand and its two complexes bind to DNA via a groove binding mode, and the binding affinity of the complex 2 is higher than that of the complex 1 and the ligand. Furthermore, the antioxidant activity (superoxide and hydroxyl radical) of the ligand and its metal complexes was determined by using spectrophotometer methods in vitro. These complexes were found to possess potent antioxidant activity and be better than standard antioxidants like vitamin C and mannitol. In particular, complex 2 displayed excellent activity on the superoxide and hydroxyl radical.

• 公益社団法人日本薬学会の論文
• 2008-04-01

著者

• Chen Feng-juan

  State Key Laboratory Of Applied Organic Chemistry And College Of Chemistry And Chemical Engineering

• XI Pin-Xian

  State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering,

• XU Zhi-Hong

  State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering,

• LIU Xiao-Hui

  State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering,

• HUANG Liang

  State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering,

• ZENG Zheng-Zhi

  State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering,

• Xi Pin-xian

  Coll. Of Chemistry And Chemical Engineering And State Key Lab. Of Applied Organic Chemistry Lanzhou

• Zeng Zheng-zhi

  Coll. Of Chemistry And Chemical Engineering And State Key Lab. Of Applied Organic Chemistry Lanzhou

• Huang Liang

  State Key Laboratory Of Applied Organic Chemistry And College Of Chemistry And Chemical Engineering

• Xu Zhi-Hong

  State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University

関連論文

• Synthesis, Characterization, Antioxidant Activity, and DNA-Binding Studies of 1-Cyclohexyl-3-tosylurea and Its Nd(III), Eu(III) Complexes

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