Design, Synthesis and Anti Flaviviridae Activity of N^6-,5',3'-O- and 5',2'-O-Substituted Adenine Nucleoside Analogs
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概要
- 論文の詳細を見る
During a random screening of representative libraries of nucleoside analogues we discovered that the adenine derivatives FEVB28 and FEG118 were Flaviviridae inhibitors endowed with potency comparable, if not superior, to that of ribavirin. Those studies prompted us to design a new class of protected nucleoside analogs, reported herein, which displays interesting anti-bovine viral diarrhea virus (BVDV) activity and low cytotoxicity in cell-based assays (4, 23, 29 EC_<50>: 14, 11, 26 μM respectively, CC_<50>>100μM) and appreciable activity in enzyme assays against the RNA dependent RNA polymerase (RdRp) of BVDV (4, 23, 29, RdRp inhibition activity 27, 16, 15μM respectively). A molecular modeling study was also carried out to highlight the possible interactions between this compounds class and the corresponding hepatitis C virus (HCV) enzyme.
- 公益社団法人日本薬学会の論文
- 2008-04-01
著者
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La Colla
Department Of Biomedical Sciences And Technologies University Of Cagliari
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Sanna Tiziana
Department Of Biomedical Sciences And Technologies University Of Cagliari
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ANGUSTI Angela
Department of Pharmaceutical Sciences, University of Ferrara
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MANFREDINI Stefano
Department of Pharmaceutical Sciences, University of Ferrara
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DURINI Elisa
Department of Pharmaceutical Sciences, University of Ferrara
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CILIBERTI Nunzia
Department of Pharmaceutical Sciences, University of Ferrara
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VERTUANI Silvia
Department of Pharmaceutical Sciences, University of Ferrara
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SOLAROLI Nicola
Department of Pharmaceutical Sciences, University of Ferrara
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PRICL Sabrina
Molecular Simulation (MOSE) Laboratory, Department of Chemical Engineering, University of Trieste
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FERRONE Marco
Molecular Simulation (MOSE) Laboratory, Department of Chemical Engineering, University of Trieste
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FERMEGLIA Maurizio
Molecular Simulation (MOSE) Laboratory, Department of Chemical Engineering, University of Trieste
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LODDO Roberta
Department of Biomedical Sciences and Technologies, University of Cagliari
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SECCI Barbara
Department of Biomedical Sciences and Technologies, University of Cagliari
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VISIOLI Anna
Department of Biomedical Sciences and Technologies, University of Cagliari
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COLLU Gabriella
Department of Biomedical Sciences and Technologies, University of Cagliari
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PEZZULLO Margherita
Department of Biomedical Sciences and Technologies, University of Cagliari
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Visioli Anna
Department Of Biomedical Sciences And Technologies University Of Cagliari
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Durini Elisa
Department Of Pharmaceutical Sciences University Of Ferrara
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Ferrone Marco
Molecular Simulation (mose) Laboratory Department Of Chemical Engineering University Of Trieste
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Loddo Roberta
Department Of Biomedical Sciences And Technologies University Of Cagliari
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Secci Barbara
Department Of Biomedical Sciences And Technologies University Of Cagliari
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Pricl Sabrina
Molecular Simulation (mose) Laboratory Department Of Chemical Engineering University Of Trieste
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Angusti Angela
Department Of Pharmaceutical Sciences University Of Ferrara
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Collu Gabriella
Department Of Biomedical Sciences And Technologies University Of Cagliari
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Solaroli Nicola
Department Of Pharmaceutical Sciences University Of Ferrara:division Of Metabolic Diseases Karolinsk
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Vertuani Silvia
Department Of Pharmaceutical Sciences University Of Ferrara
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Ciliberti Nunzia
Department Of Pharmaceutical Sciences University Of Ferrara
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Fermeglia Maurizio
Molecular Simulation (mose) Laboratory Department Of Chemical Engineering University Of Trieste
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Pezzullo Margherita
Department Of Biomedical Sciences And Technologies University Of Cagliari
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Manfredini Stefano
Department Of Pharmaceutical Sciences University Of Ferrara