Correlative Expression of Cyclooxygenase-1 (Cox-1) and Human Epidermal Growth Factor Receptor Type-2 (Her-2) in Endometrial Cancer
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概要
- 論文の詳細を見る
Objectives: Cyclooxygenase-2 (Cox-2) is known to be associated with tumorigenesisin many cancers including endometrial cancer, while there is substantial evidence forthe tumorigenicity of cyclooxygenase-1 (Cox-1). However, little is known about theinvolvement of Cox-1 in the development of endometrial cancer. The aim of this studywas to determine whether cyclooxygenase-1 or -2 (Cox-1, Cox-2) is tumorigenetic, aswell as whether these two cyclooxygenase isoforms correlate with theclinicopathological characteristics or with another two biomarkers, human epidermalgrowth factor receptor type-2 (Her-2) and vascular endothelial growth factor (VEGF),of endometrial cancer.Methods: At first, Cox-1 and Cox-2 levels in eight endometrial cancer cell lines weredetermined by means of real-time PCR. At second, the levels of four biomarkers (Cox-1,Cox-2, Her-2, and VEGF) in 70 endometrial cancer samples were determined by meansof real-time PCR. Pairs of these biomarkers were subjected to correlation as eachbiomarker and clinical status or survival.Results: In the eight cell lines, the expression of Cox-1 and Cox-2 showed majorvariations in their mRNA levels. Analysis of the patient samples showed that the mRNAexpression of Cox-1 was elevated significantly in the G1 (P=0.021) and G2 (P=0.036)groups, as was the mRNA expression of Her-2 in the two groups (P=0.036 and P=0.0029,respectively). The mRNA expression of Cox-1 and Her-2 were correlated (CI=0.671).None of the three biomarkers, Cox-1, Cox-2, and Her-2, was correlated with clinicalstatus such as FIGO classification, myometrial invasion, or clinical outcome.Conclusion: Cox-1, together with Her-2, may be involved in the early stage ofendometrial cancer development.
- 神戸大学の論文
著者
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KUMAGAI Shunichi
Department of Clinical Laboratory, Kobe University Hospital
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Kumagai Shunichi
Department Of Clinical Pathology And Immunology Kobe University Graduate School Of Medicine
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Sugimoto Takeshi
Clinical Research Division Hyogo Medical Center For Adults
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Kojima Atsumi
Clinical Research Division Hyogo Medical Center For Adults
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Koizumi Tamio
Clinical Research Division Hyogo Medical Center For Adults
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Sudo Tamotsu
Clinical Research Division, Hyogo Medical Center for Adults
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Yamaguchi Satoshi
Gynecology and Oncology Division, Hyogo Medical Center for Adults
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Nishimura Ryuichirou
Clinical Research Division, Hyogo Medical Center for Adults
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Sudo Tamotsu
Clinical Research Division Hyogo Medical Center For Adults
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Nishimura R
Clinical Research Division Hyogo Medical Center For Adults
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Yamaguchi Satoshi
Gynecology And Oncology Division Hyogo Medical Center For Adults
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