金属錯体による実験糖尿病の治療(誌上シンポジウム)

スポンサーリンク

概要

• 論文の詳細を見る

• The number of patients suffered from diabetes mellitus has increased over the decades probably because of both lifestyle-and diet-changes. There are two types of diabetes mellitus. Type 1 diabetes mellitus is due to the autoimmune-mediated destruction of pancreatic B cells, which results in absolute insulin deficiency, thus the patients require insulin injections. Type 2 diabetes mellitus is due to the insulin resistance and abnormal insulin secretion, thus the patients require exercise, diet control and/or oral hypoglycemic medicines. Each treatment, however, has some problems involving physical and mental burden, and formation of self-antibodies for insulin injections, and the severe side effects and discontinuation of insulin synthesis in the pancreas for hypoglycemic medicines. To overcome these important problems and find the replacements for the insulin injections and synthetic medicines, we attempted to develop new antidiabetic metallocomplexes with novel structures and mechanisms. In 1990, we first presented orally active vanadyl (+4 oxidation state of oxo-vanadium) complexes including vanadyl-cysteine methyl ester complex, which normalized hyperglycemia in the streptozocin (STZ)-induced type 1 diabetic rats. Based on these findings, we have developed a wide variety of vanadyl complexes with different coordination environments around vanadyl ion. Following the study, we also challenged to develop orally active zinc complexes since 2002. This review focuses on our recent development of vanadyl and zinc complexes for anti-diabetic and anti-metabolic syndromes, together with the propose for the possible action mechanism of these complexes in adipocytes.

• 公益社団法人日本薬学会の論文
• 2008-03-01

著者

• 桜井 弘

  鈴鹿医療科学大学東洋医学研究所

• 桜井 弘

  鈴鹿医療科学大学 薬学部

• 桜井 弘

  鈴鹿医療科学大学

関連論文

• 金属 バナジウム (広範囲 血液・尿化学検査 免疫学的検査(第7版・2)その数値をどう読むか) -- (生化学的検査(2))
• 金属錯体による実験糖尿病の治療(誌上シンポジウム)
• 金属で病気は治せるか?(誌上シンポジウム)
• 21世紀における微量元素研究(Metallomics)への期待と展望--私的提案
• 人気のミネラルウォーターの秘密
• 糖尿病やメタボリックシンドロームを治す金属錯体
• 糖尿病克服を目指した新規亜鉛錯体の開発研究に挑む
• 人気のミネラルウォーターの秘密(レーダー)
• 糖尿病やメタボリックシンドロームを治す金属錯体(レーダー)
• Copper Compounds Ameliorate Cardiovasclur Dysfunction and Diabetes in Animals
• 21世紀における微量元素研究(Metallomics)への期待と展望 : 私的提案

もっと見る 閉じる

スポンサーリンク