Developmental and Spatial Expression of sir2 Genes in the Cellular Slime Mold Dictyostelium discoideum

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概要

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• The cellular slime mold Dictyostelium discoideum grows as unicellular free-living amoebae in the presence of nutrients. Upon starvation, the amoebae aggregate and form multicellular structures that each consist of a stalk and spores. D. discoideum encodes at least four proteins (Sir2A, Sir2B, Sir2C, and Sir2D) homologous to human SIRT. RT-PCR and WISH analyses showed that the genes for Sir2A, Sir2C, and Sir2D were expressed at high levels in growing cells but at decreased levels in developing cells, whereas the gene encoding Sir2B was expressed in the prestalk-cell region in the developmental phase.

著者

• Katayama Takahiro

  Graduate School Of Science And Engineering University Of Toyama

• Yasukawa Hiro

  Graduate School Of Science And Engineering University Of Toyama

関連論文

• Analysis of Sir2E in the cellular slime mold Dictyostelium discoideum : Cellular localization, spatial expression and overexpression
• Developmental and Spatial Expression of sir2 Genes in the Cellular Slime Mold Dictyostelium discoideum

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