Elevation of Plasma Corticosterone Levels and Hippocampal Glucocorticoid Receptor Translocation in Rats : a Potential Mechanism for Cognition Impairment Following Chronic Low-power-density Microwave Exposure

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概要

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• The goal of this study was to investigate whether glucocorticoids (GCs) take part in cognition impairment after exposure to chronic low-power-density microwave (MW) fields. We exposed Wistar rats to a 2.45-GHz pulsed MW field at an average power density of 1 mW/cm^2 for 3 h daily, for up to 30 days. Our results show that MW-exposed rats had significant deficits in spatial learning and memory performance. MW exposure increased levels of plasma corticosterone, and consequently GC receptor (GR) nuclear translocation and apoptosis in the hippocampus. However, co-administration of the GR antagonist RU486 with MW exposure partially reversed the cognitive impairment and neuronal loss. These data indicate that GCs might contribute to the cognition deficit induced by chronic low-power-density MW exposure.

• 2008-03-16

著者

• Zhang Yanwen

  Department Of Occupational Health The Third Military Medical University

• LI Maoquan

  Department of Public Health, Chengdu Medical College

• WANG Yanyan

  Department of Medical Genetics, The Third Military Medical University

• ZHOU Zhou

  Department of Occupational Health, The Third Military Medical University

• YU Zhengping

  Department of Occupational Health, The Third Military Medical University

• Li Maoquan

  Department Of Public Health Chengdu Medical College

• Wang Yanyan

  Department Of Forensic Science Chinese People's Public Security University

• Wang Yanyan

  Department Of Medical Genetics The Third Military Medical University

• Yu Zhengping

  Department Of Occupational Health The Third Military Medical University

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• Elevation of Plasma Corticosterone Levels and Hippocampal Glucocorticoid Receptor Translocation in Rats : a Potential Mechanism for Cognition Impairment Following Chronic Low-power-density Microwave Exposure
• Metalloid Resistance Mechanisms in Prokaryotes

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