ミオグロビンによる實驗的心筋炎(第1報)

概要

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I studied Whether myoglodin (to de abbreviated hereafter to mb)-antibodies in rice-illness causes allergic changes in catdiac tissue and the other organs. Furthermore, I investigated pathologic-histologically the relation of this phenomenon to the pathogenesis of so-called beriberi heart. This experiment consists of two groups. I group employinf antichickness mb (in rice-illness) rabbit immune serum, II group being sensitized over and over agein with chickness mb in rice-illness. Results obtained are summarized in the following. I group:- Speaking of heart treated, the allergic myocarditis occarred in all cases, especially with perivascular or interstitial cell-infiltration, fibrinoid degeneration of wall of blood vessels and degeneration of heart muscles. On the other hand, interstitial cell-infiltration in liver, proliferation of interstitium, swelling or desq-u amation of epithelium of tuble and proliferation of gromelurus epithelium in kidney, and perivascular cell infiltration in sceletal muscles etc. were also observed. But the group treated with myosin and myogen showed slight pathological changes.
社団法人日本循環器学会の論文
1954-05-20