特發性脱疽の「アレルギー」性本態に關する研究補遺
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概要
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I. Hiatological Examination. To solve the problem of the allergic nature of thromboangiitis obliterans, detailed histological examinations have been made in amputated limbs, cervical muscles, lumbar sympathetic ganglia etc. Results obtained are summarized in the following. 1. More or less histological changes can be observed everywhere in the body. 2. Histological findings characterizing allergy are found in blood vessels, muscles and peripheral nerves. 3. There are morphological evidences of the repeated occurrence of allergic reaction, explaining the progressive nature of the disease. 4. Althuogh an unknown allergy may be the primary cause, it is possible that additional changes take place as a result of another allergy from the infected and devitalized tissue in the gangrene. 5. The thrombosis in large blood vessels is supposed with good reasons to follow the allergic changes of vasa vasarum in thrombosed areas. 6. In this diseases, marked vascular newformation in rete arteriosus cutaneum is observed in feet and toes. As E. Jaeger has suggested, the constriction of these cutaneous arterioles may be the cause of aggravation of symptoms in cold winter. 7. The disturbance of blood supply and the degeneration of nerve fibers undoubtedly take some part in the occurrence of organic changes in the disease. II. Clinical Statistics 1. In my series of 185 patients of thromboangiitis obliterans, there are clinical evidences showing that it is a generalized disease. 2. In the heredity and past history of patients an allergic disposition is apparently suggested.
- 社団法人日本循環器学会の論文
- 1951-03-20