ヂギタリス有効成分に關する臨牀的研究 : ヂギコール,ヂギコリン,ヂギトキシン,ギトキシン,ヂギタリス葉末の効果比較,殊に大量屯用后に於ける効果の發現持續に就いて
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概要
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The cardiotonic effects of digicorin (digicor), digitoxin, gitoxin and digitalis leaves were comparatively studied in fortjr patients with congestive heart failure, whom one large single dose of each drug amounting to 1〜5mg. (2〜5gm.), 1〜1.5mg., 2〜5mg. and 1〜1.5gm. respectively were administered orally. In .this study seventy observations were made, wherein the heart rate, pulse deficit if present, respiration rate, blood pressure, circulation time and urine volume were followed besides the changes of cardiac symptoms. The side reactions were also observed. Depending upon the results obtained, the following conclusions were induced. 1. Digitoxin is the most akin to digitalis leaves in the mode of its action and the strength of its effects. 2. Digicorin or Digicor is less effective as Compared with digitoxin, but action of the former is more rapid and the side effects are far less. 3. The cardiotonic effects of gitoxin is the poorest.
- 社団法人日本循環器学会の論文
- 1950-01-20