Effect of hydroxyapatite-coated nanofibrous membrane on the responses of human periodontal ligament fibroblast(<Feature> Ceramics for Biomedical Applications in Asian Countries)
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概要
- 論文の詳細を見る
In this study, hydroxyapatite-coated biopolymer nanofibrous membrane was synthesized by mineralizing the electrospun polycaprolactone nanofiber. The effect of the hydroxyapatite-coated nanofibrous membrane was mainly investigated on the proliferation and differentiation of human periodontal ligament fibroblast, which is necessary for periodontal tissue regeneration. Scanning electron microscopy revealed favorable cell attachment and spreading appearance on 1d and MTS assay showed increased cell proliferation on the hydroxyapatite-coated nanofiber membrane during 14d. From 7 to 14d, alkaline phosphatase activity of the hydroxyapatite-coated nanofiber was significantly increased when compared to that of control group. Hydroxyapatite-coated nanofibrous membrane showed prominent mineral formation on day 14. As a result, it was clarified that the developed hydroxyapatite-coated nanofibrous membrane had favorable effects on the proliferation and differentiation of human periodontal ligament fibroblast and might be a good candidate material for periodontal tissue regeneration.
- 社団法人日本セラミックス協会の論文
- 2008-01-01
著者
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Lee Seung-jin
Department Of Oral Anatomy School Of Dentistry
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LEE Hae-Hyoung
Department of Biomaterials Science, Dankook University School of Dentistry
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Lee Seung-pyo
Department Of Oral Anatomy School Of Dentistry
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Lee Hae-hyoung
Department Of Biomaterials Science & Institute Of Tissue Regeneration Engineering School Of Dent
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PARK Sun-Hye
Department of Periodontology, Dental Research Institute, School of Dentistry
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KIM Tae-Il
Department of Periodontology, Dental Research Institute, School of Dentistry
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KU Young
Department of Periodontology, Dental Research Institute, School of Dentistry
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CHUNG Chong-Pyoung
Department of Periodontology, Dental Research Institute, School of Dentistry
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HAN Soo-Boo
Department of Periodontology, Dental Research Institute, School of Dentistry
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YU Ji-Hee
Department of Oral anatomy, School of Dentistry
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KIM Hae-Won
Department of Biomaterials Science & Institute of Tissue Regeneration Engineering, School of Dentist
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Yu Ji-hee
Department Of Oral Anatomy School Of Dentistry
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Han Soo-boo
Department Of Periodontology Dental Research Institute School Of Dentistry
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Ku Young
Department Of Periodontology Dental Research Institute School Of Dentistry
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Ku Young
Department Of Periodontology College Of Dentistry Seoul National University
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Kim Tae-il
Department Of Periodontology Dental Research Institute School Of Dentistry
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Kim Tae-il
Department Of Periodontology College Of Dentistry Seoul National University
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Chung Chong-pyoung
Department Of Periodontology College Of Periodontology Seoul National University
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Chung Chong-pyoung
Department Of Periodontology College Of Dentistry Seoul National University
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Chung Chong-pyoung
Department Of Periodontology Dental Research Institute School Of Dentistry
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Kim Hae-won
Department Of Biomaterial Science Dankook University School Of Dentistry
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Kim Hae-won
Department Of Biomaterials Science & Institute Of Tissue Regeneration Engineering School Of Dent
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Park Sun-hye
Department Of Periodontology Dental Research Institute School Of Dentistry
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