ビタミンAと発生(<特集>「ビタミン・ミネラルと生殖」[I])

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概要

• 論文の詳細を見る

• Vitamin A plays a key role in a variety of biological processes in adults and is essential for normal embryonic development. Retinoic acid (RA), an oxidation product of vitamin A, plays complex and diverse roles during embryogenesis but both excess and lack of RA is a potent teratogen in rodents and humans. Since the discovery of RA receptors in 1980's, various mutant mice have been reported including RA receptors, RA binding protein, and RA synthesizing or degrading enzymes to elucidate functions during embryogenesis. I would summarize these phenotypes of mutant mice and refer how RA plays important roles during normal development, especially focusing on hindbrain, vertebra, and limb development.

• 日本ビタミン学会の論文
• 2008-01-25

著者

• 岡野 純子

  京都大学大学院医学研究科附属先天異常標本解析センター

関連論文

• ビタミンAと発生(「ビタミン・ミネラルと生殖」[I])

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