Creation of a composite of collagen and OCP crystals with large morphological anisotropy
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概要
- 論文の詳細を見る
Collagen and octacalcium phosphate (OCP) crystals of micrometer size with anisotropic morphology were combined under physiological temperature and pH. OCP crystals elongated in the c-axis direction were grown in a reaction chamber where diffusion was controlled by a cation selective membrane. The size of crystal used was 40-50μm in length, about 2μm in width and aspect ratio of around 20-25. Atelocollagen was reconstituted and cross-linked in the presence of the crystals at 37℃ for 20-48h under stirring. Despite stirring and mixing during fabrication process, the long crystals assembled with reconstituted collagen fibers and arranged more or less parallel to each other along the collagen fibers. This suggested that OCP crystals and collagen fibers assembled through some interaction, by which crystals stayed on/between collagen fibers during fabrication process. Collagen content of resultant composites was arbitrarily changeable in the range of 20-90% by weight. Thus, the composite of long OCP crystals and collagen was newly designed for future application as a bone substitute material.
- 社団法人日本セラミックス協会の論文
- 2008-02-01
著者
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IIJIMA Mayumi
Asahi University School of Dentistry, Dental Materials Science
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DOI Yutaka
Asahi University School of Dentistry, Dental Materials Science
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Doi Yutaka
Dep. Of Dental Materials Sci. Div. Of Oral Functional Sci. And Rehabilitation Asahi Univ. School Of
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Doi Yutaka
Asahi University School Of Dentistry Dental Materials Science
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Iijima Mayumi
Asahi University School Of Dentistry Dental Materials Science
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Kamemizu Hideo
Dep. Of Dental Materials Sci. Div. Of Oral Functional Sci. And Rehabilitation Asahi Univ. School Of
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WAKAMATU Nobukazu
Asahi University School of Dentistry, Dental Materials Science
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KAMEMIZU Hideo
Asahi University School of Dentistry, Dental Materials Science
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ADACHI Masanori
Asahi University School of Dentistry, Dental Materials Science
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Wakamatsu Nobukazu
Dep. Of Dental Materials Sci. Div. Of Oral Functional Sci. And Rehabilitation Asahi Univ. School Of
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Doi Yutaka
Asahi Univ. School Of Dentistry Mizuho Jpn
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ADACHI Masanori
Department of Dental Materials and Science, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry
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