Withangulatin I, a New Cytotoxic Withanolide from Physalis angulata

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概要

• 論文の詳細を見る

• A new withanolide, withangulatin I (2), was isolated from the whole plant of Physalis angulata. Its structure was established as (20S, 22R)-15α-acetoxy-5β, 6β-epoxy-14α-hydroxy-1, 4-dioxo-witha-2, 16, 24-trienolide on the basis of chemical and spectroscopic methods including 2D-NMR and circular dichroism (CD) experiments. Withangulatin A (1) and withangulatin I (2) were tested for their cytotoxic activities against two human cancer cell lines, colorectal carcinoma COLO 205 and gastric carcinoma AGS, in vitro. Compounds 1 and 2 exhibited inhibitory activities against these two human cancer cells with IC_<50> values of 16.6 and 1.8 and 53.6 and 65.4μM, respectively.

• 公益社団法人日本薬学会の論文
• 2008-02-01

著者

• CHEN Chiu-Ming

  Department of Chemistry, National Tsing Hua University

• Chen Chiu-ming

  Department Of Chemistry National Tsing Hua University

• PAN Min-Hsiung

  Department of Seafood Science, National Kaohsiung Marine University

• Pan Min-hsiung

  Department Of Seafood Science National Kaohsiung Marine University

• LEE Shwu-Woan

  Department of Applied Chemistry, Chia-Nan University of Pharmacy and Science

• CHEN Zong-Tsi

  Department of Applied Chemistry, Chia-Nan University of Pharmacy and Science

• Lee Shwu-woan

  Department Of Applied Chemistry Chia-nan University Of Pharmacy And Science

• Chen Zong-tsi

  Department Of Applied Chemistry Chia-nan University Of Pharmacy And Science

関連論文

• Chemical and Chemotaxonomical Studies of Ferns. LXXX. : Proanthocyanidins of Arachniodes sporadosora NAKAIKE and A. exilis CHING
• Lanostane-Type Triterpenoids from Diospyros discolor
• Withangulatin I, a New Cytotoxic Withanolide from Physalis angulata
• Cucurbitacin B 2-Sulfate and Cucurbitacin Glucosides from the Root Bark of Helicteres angustifolia

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