Evaluation of the Radioprotective Effects of Propolis and Flavonoids in Gamma-Irradiated Mice : The Alkaline Comet Assay Study(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
The radioprotective effects of water-soluble derivate of propolis (WSDP) collected in Croatia, and single flavonoids, caffeic acid, chrysin and naringin in the whole-body irradiated CBA mice were investigated. Irradiation was performed using a γ-ray source (^<60>Co), and absorbed doses were 4 and 9Gy. The efficiency of test components was evaluated when given intraperitoneally (i.p.) at dose of 100mg kg^<-1> for 3 consecutive days before and/or after irradiation. Moreover, possible genotoxic effects of all test components were assessed on non-irradiated animals. The higher efficiency of test components was observed when given preventively. The results suggest that propolis and related flavonoids given to mice before irradiation protected mice from lethal effects of wholebody irradiation and diminish primary DNA damage in their white blood cells as detected by the alkaline comet assay.
- 2008-01-01
著者
-
BENKOVIC Vesna
Department of Animal Physiology, Faculty of Science, University of Zagreb
-
ORSOLIC Nada
Department of Animal Physiology, Faculty of Science, University of Zagreb
-
HORVAT KNEZEVIC
Department of Animal Physiology, Faculty of Science, University of Zagreb
-
RAMIC Snjezana
University Hospital for Tumors
-
DIKIC Domagoj
Department of Animal Physiology, Faculty of Science, University of Zagreb
-
BASIC Ivan
Department of Animal Physiology, Faculty of Science, University of Zagreb
-
KOPJAR Nevenka
Institute for Medical Research and Occupational Health
-
Basic Ivan
クロアチア
-
Basic Ivan
Department Of Animal Physiology Faculty Of Science University Of Zagreb
-
Orsolic Nada
クロアチア
-
Orsolic Nada
Department Of Animal Physiology Faculty Of Science University Of Zagreb
-
Dikic Domagoj
Department Of Animal Physiology Faculty Of Science University Of Zagreb
-
Benkovic Vesna
Department Of Animal Physiology Faculty Of Science University Of Zagreb
-
Horvat Knezevic
Department Of Animal Physiology Faculty Of Science University Of Zagreb
関連論文
- Evaluation of the Radioprotective Effects of Propolis and Flavonoids in Gamma-Irradiated Mice : The Alkaline Comet Assay Study(Biopharmacy)
- Evaluation of Radioprotective Effects of Propolis and Quercetin on Human White Blood Cells in Vitro(Biopharmacy)
- Assessment by Survival Analysis of the Radioprotective Properties of Propolis and Its Polyphenolic Compounds(Biopharmacy)
- Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells
- Effects of Local Administration of Propolis and Its Polyphenolic Compounds on Tumor Formation and Growth(Biopharmacy)
- Synergystic Antitumor Effect of Polyphenolic Components of Water Soluble Derivative of Propolis against Ehrlich Ascites Tumour(Biopharmacy)