Redox Regulation in the Extracellular Environment

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概要

• 論文の詳細を見る

• The oxidizing nature of the extracellular environment is vastly different from the highly reducing nature of the intracellular compartment. The redox potential of the cytosolic compartment of the intracellular environment limits disulfide bond formation, whereas the oxidizing extracellular environment contains proteins rich in disulfide bonds. If not for an extracellular antioxidant system to eliminate reactive oxygen and nitrogen species, lipid peroxidation and protein oxidation would become excessive, resulting in cellular damage. Many reviews have focused on the role of intracellular antioxidants in the elimination of oxidative stress, but this one will focus on the coordinated action of both intracellular and extracellular antioxidants in limiting cellular oxidant stress.

• 社団法人日本循環器学会の論文
• 2007-12-20

著者

• LOSCALZO Joseph

  Department of Medicine, Brigham and Women's Hospital, Harvard Medical School

• Loscalzo Joseph

  Department Of Medicine Brigham And Women's Hospital Harvard Medical School

• Ottaviano Filomena

  Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medi

• Handy Diane

  Department of Medicine, Brigham and Women's Hospital, Harvard Medical School

• Handy Diane

  Department Of Medicine Brigham And Women's Hospital Harvard Medical School

• Ottaviano Filomena

  Whitaker Cardiovascular Institute And Evans Department Of Medicine Boston University School Of Medic

関連論文

• The effect of salt on renal damage in eNOS-deficient mice
• Redox Regulation in the Extracellular Environment
• Physiological stress increases renal injury in eNOS-knockout mice

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