Coupling circadian rhythm and cell cycle (MEとバイオサイバネティックス)

概要

論文の詳細を見る
Circadian and cell cycles are suggested to be linked at molecular level. In order to elucidate the mechanism of interactions, we first established a model for cell cycle in eukaryotes, which involves Cyclin: CDK, CDC25, Wee1, Cyclin: CDK: CKI, SKP2, APC and CDC20. Because Wee1 is suggested to be a candidate to establish the link, phase responsiveness was investigated by applying a perturbation on Wee1 transcription in the model. We found that the growth curve of cell mass has a critical role in the responsiveness. The model with a power law growth curve exhibited a PRC with only a delay response, which will be used to study circadian regulations on cell cycle.
社団法人電子情報通信学会の論文
2007-11-15