Possible Role of Extracellular Signal-Regulated Kinase Pathway in Regulation of Sox9 mRNA Expression in Chondrocytes under Hydrostatic Pressure(BIOINFORMATICS)
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概要
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The potential involvement of the extracellular signal-regulated kinase (ERK) pathway in chondrocyte mechanotransduction was tested in bovine chondrocyte-agarose constructs under hydrostatic loading. Results suggested that the ERK pathway may be inhibited by hydrostatic pressure-induced mechanotransduction and may also be a negative regulator of Sox9 mRNA expression, which is an important modulator of chondrocyte function.
- 社団法人日本生物工学会の論文
- 2007-12-25
著者
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Kirkham Jennifer
Department Of Oral Biology Leeds Dental Institute University Of Leeds
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Mio Kensuke
Academic Unit of Musculo-Skeletal and Rehabilitation Medicine, Bioengineering Division, University o
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Bonass William
Department of Oral Biology, Leeds Dental Institute, University of Leeds
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Mio Kensuke
Academic Unit Of Musculo-skeletal And Rehabilitation Medicine Bioengineering Division University Of
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Bonass William
Department Of Oral Biology Leeds Dental Institute University Of Leeds