Electrochemical Determination of the Antidiabetic Drug Repaglinide

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The electrochemical oxidation of repaglinide has been carried out in Britton-Robinson buffer at carbon paste and glassy carbon electrodes. Repaglinide exhibits a well-defined irreversible oxidation peak over the entire pH range (2-11). Differential pulse voltammetry was used to determine repaglinide in pure form. The peak current varied linearly in the following ranges: 8.0×10^<-7>-3.2×10^<-6>M and 4.0×10^<-7>-4.0×10^<-6> M in case of carbon paste electrode and glassy carbon electrode, respectively. In case of carbon paste electrode the limits of detection (LOD) and quantification (LOQ) were 1.348×10^<-7> M and 4.494×10^<-7> M, respectively. For glassy carbon electrode the LOD and LOQ were 1.062×10^<-7> M and 3.54×10^<-7> M, respectively. The percentage recoveries were found in the following ranges: 99.09-100.07% and 99.0-100.50% for carbon paste electrode and glassy carbon electrode, respectively. The relative standard deviations were found in the following ranges: 0.636-1.395% and 0.431-1.104% in case of carbon paste electrode and glassy carbon electrode, respectively. Differential pulse voltammetry was successfully applied for the determination of repaglinide in tablets and human serum.
2008-01-01