Effect of Raloxifene on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats

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概要

• 論文の詳細を見る

• The effect of raloxifene on cerebral vasospasm following experimental subarachnoid hemorrhage (SAH) was investigated in a rat model. Seven groups of seven rats underwent no SAH, no treatment; SAH only; SAH plus vehicle; SAH plus 3 days intraperitoneal raloxifene treatment; SAH plus 4 days intraperitoneal raloxifene treatment; SAH plus 3 days intrathecal raloxifene treatment; and SAH plus 4 days intrathecal raloxifene treatment. The basilar artery cross-sectional areas were measured at 72 or 96 hours following SAH. The results showed raloxifene decreased SAH-induced cerebral vasospasm in all treatment groups, and suggested no difference between intraperitoneal and intrathecal application, or between 3 days and 4 days of raloxifene treatment. The present study demonstrates that raloxifene is a potential therapeutic agent against cerebral vasospasm after SAH.

• 社団法人 日本脳神経外科学会の論文
• 2007-12-15

著者

• Gulsen Salih

  Department Of Neurosurgery Baskent University

• Gulsen Salih

  Department Of Neurosurgery Hacettepe University:(present Office)department Of Neurosurgery Faculty O

• Ozgen Tuncalp

  Department Of Neurosurgery Hacettepe University

• INCI Servet

  Departments of Neurosurgery, Hacettepe University School of Medicine

• YURUK Sinan

  Department of Histology and Embryology, Hacettepe University

• YASAR Umit

  Department of Pharmacology, Hacettepe University

• Yasar Umit

  Department Of Pharmacology Hacettepe University

• Inci Servet

  Department Of Neurosurgery Hacettepe University

• Yuruk Sinan

  Department Of Histology And Embryology Hacettepe University

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