Solution Equilibria between Aluminum(III) Ion and some Fluoroquinolone Family Members. Spectroscopic and Potentiometric Study

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概要

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• Complex formation between aluminum(III) ion and fluoroquinolone antibacterials-either moxifloxacin (4th generation antibiotic) or fieroxacin (2nd generation antibiotic) were studied in aqueous solutions without and in the presence of sodium dodecylsulfate (SDS). The investigations were performed by glass electrode potentiometric (ionic medium: 0.1 mol/dm^3 LiCl, 298 K), UV spectrophotometric, multinuclear (^1H and ^<13>C) magnetic resonance and ESI-MS measurements. The experimental data were consistent with the formation of Al(HL)L^<2+>, Al(HL)^<3+>, AIL^<2+>, Al(OH)L^+ and Al(OH)_2L complexes in the pH interval ca. 3-8 and up to 5:1 ligand to metal mole ratio with range of Al^<3+> concentrations between ca. 0.025 to 1.0 mmol/dm^3. The binary complex, AlL^<2+> is fairly stable (logβ_<1, 0, 1> ca. 11.0) and its stability increases in the presence of SDS. At higher concentration ratios of ligands to aluminum, up to 5:1, the complex Al(HL)L^<2+> is formed with rather high overall stability constant (logβ_<1, 1, 2> ca. 24.0). The ESI-MS data generally, confirmed the derived model, and the formation of the complex with ligand to metal ratio 2:1. NMR measurements indicate that both ligands utilize 4-carbonyl and carboxyl oxygens as donor atoms. The presence of surface active substance, SDS, favors the formation of the complex in which the ligand is protonated, i.e. Al(HL) and its maximum formation is shifted toward milder acidic region (pH ca. 4). The aluminum-quinolone complexes may affect the bio-distribution of both, quinolone and/or aluminum ion upon concomitant ingestion of aluminum-based antacids or phosphate binders and fluoroquinolones.

• 公益社団法人日本薬学会の論文
• 2007-12-01

著者

• Joksovic Ljubinka

  Faculty Of Science Institute Of Chemistry

• DJURDJEVIC Predrag

  Faculty of Science, Institute of Chemistry

• JELIC Ratomir

  Faculty of Science, Institute of Chemistry

• DJURDJEVIC Aleksandra

  Agency for Medicines and Medical Devices

• STANKOV Milena

  Faculty of Pharmacy

• Jelic Ratomir

  Faculty Of Science Institute Of Chemistry

• Djurdjevic Predrag

  Faculty Of Science

• Djurdjevic Predrag

  Faculty Of Science Institute Of Chemistry

関連論文

• Solution Equilibria between Aluminum(III) Ion and some Fluoroquinolone Family Members. Spectroscopic and Potentiometric Study
• The Effect of Surfactants on Equilibria in Aluminium(III) Ion + Ofloxacin Solution and Adsorption of Ofloxacin on Aluminium-Oxide
• Optimization and validation of the direct HPLC method for the determination of moxifloxacin in plasma

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