Comparison of Bioactivities of 5-Fluoro, 5-Iodo, 5-Iodovinyl, and 5-Fluorovinyl Arabinosyl Uridines against SR-39 TK-Transfected Murine Prostate Cancer Cells
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概要
- 論文の詳細を見る
A cell survival assay of the four arabinosyl uridine analogs with functionalities of 5-fluoro, 5-fluorovinyl, 5-iodo, and 5-iodovinyl as potential positron-emitter tagged probe for monitoring cancer gene therapy were performed. Cytotoxicities of 5-fluoro-, 5-iodo-, 5-fluorovinyl, and 5-iodovinyl arabinosyl uridines against SR-39 thymidine kinase transfected murine prostate cancer cells have been evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. None of them showed significant bioactivity. A syn conformation derived from intra-hydrogen bonding was suggested for the unfavorable interaction and diminished bioactivity.
- 公益社団法人日本薬学会の論文
- 2008-01-01
著者
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Lo Jem-mau
Department Of Biomedical Engineering And Environmental Sciences National Tsing-hua University
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CHIANG Chi-Shiun
Department of Biomedical Engineering and Environmental Sciences, National Tsing-Hua University
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YU Ching-Fang
Department of Biomedical Engineering and Environmental Sciences, National Tsing-Hua University
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CHIANG Li-Wu
Department of Biomedical Engineering and Environmental Sciences, National Tsing-Hua University
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CHEN Shao-Wei
Department of Biomedical Engineering and Environmental Sciences, National Tsing-Hua University
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YU Chung-Shan
Department of Biomedical Engineering and Environmental Sciences, National Tsing-Hua University
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Yu Chung-shan
Dep. Of Biomedical Engineering And Environmental Sciences National Tsing-hua Univ.
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Chiang Chi-shiun
Department Of Biomedical Engineering And Environmental Sciences National Tsing-hua University
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Chiang Chi-shiun
Department Of Biomedical Engineering And Environmental Sciences National Tsing Hua University
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Lo Jem-mau
Department Of Biomedical Engineering And Environmental Sciences National Tsing Hua University
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Yu Ching-Frag
Department of Biomedical Engineering and Environmental Sciences, National Tsing-Hua University
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