ラット血管平滑筋のヒスタミンH_1受容体を介する収縮反応

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概要

• 論文の詳細を見る

• Rat blood vessels were reported not to constrict to histamine, and histamine-induced contraction at high concentration was mediated through α_1-adrenoceptors. In the present study, it was shown that rat arteries and veins constricted to histamine at low concentration (0.1-100μM) in a non-cumulative manner and that this contraction immediately desensitized. A histamine H_1 receptor antagonist, mepyramine, abolished this transient contraction completely, whereas cimetidine, phentolamine, reserpine and tetrodotoxin failed to inhibit the contraction, indicating that the contraction is mediated directly through H_1 receptor. H_1 receptor mRNA expression level detected by RT-PCR was quite parallel to H_1 receptor-mediated contraction in the vessels.

• 新潟大学の論文

著者

• 朴 紅蘭

  新潟大学医歯学総合研究科・分子細胞医学専攻薬理学分野

関連論文

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• ラット血管平滑筋のヒスタミンH_1受容体を介する収縮反応

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