Glycine Inhibits Melanogenesis in Vitro and Causes Hypopigmentation in Vivo(Pharmacology)

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概要

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• The simplest amino acid, glycine, is important in protein composition and plays a significant role in numerous physiological events in mammals. Despite the inhibitory effect of glycine on spontaneous melanogenesis in B16F0 melanoma cells, the details of the underlying mechanisms remain unknown. The present study was conducted to investigate the further effects and the mechanisms of inhibitory effect of glycine on melanogenesis using B16F0 melanoma cells and hair follicle melanogenesis in C57BL/6J mice. Treatment with glycine (1-16mM) for 72h inhibited α-melanocyte stimulating hormone (α-MSH)-induced melanogenesis in a concentration-dependent manner without any effects on cell proliferation in B16F0 melanoma cells. Treatment with kojic acid (2.5mM) for 72h also inhibitedα-MSH-induced melanogenesis in B16F0 melanoma cells. The highest dose of glycine inhibited theα-MSH-induced increment of tyrosinase protein levels in B16F0 melanoma cells. In hair follicle melanogenesis in C57BL/6J mice, treatment with glycine (1250 or 2500mg/kg, i.p.) for 5d prevented the decrement of L^* and C^* values and inhibited the increment of tyrosinase protein levels and melanin content within the skin. Treatment with hydroquinone (100mg/kg, i.p.) for 5d had a similar hypopigmenting effect to that of high dose glycine. These results suggest that glycine has an inhibitory effect on melanogenesis that is mediated by down-regulation of tyrosinase protein levels, leading to a hypopigmenting effect in C57BL/6J mice.

• 社団法人日本薬学会の論文
• 2007-11-01

著者

• Kawase Ichiro

  Drug Evaluation Department Life Science Institute Ssp Co. Ltd.

• ISHIKAWA Masago

  Drug Evaluation Department, Life Science Institute, SSP CO., LTD.

• ISHII Fumio

  Drug Evaluation Department, Life Science Institute, SSP CO., LTD.

• Ishii Fumio

  Drug Evaluation Department Life Science Institute Ssp Co. Ltd.

• Ishii Fumio

  エスエス製薬

• Ishikawa Masago

  Drug Evaluation Department Life Science Institute Ssp Co. Ltd.

関連論文

• Glycine Inhibits Melanogenesis in Vitro and Causes Hypopigmentation in Vivo(Pharmacology)
• Combination of Amino Acids Reduces Pigmentation in B16F0 Melanoma Cells(Pharmacology)
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