孵化鶏卵による結核アレルギーの研究 : 特に結核におけるアレルギーと免疫の関係について
スポンサーリンク
概要
- 論文の詳細を見る
Varying doses of avian type of tubercle bacilli (strain Takeo) were injected into yolk sacs of developing chick embryos simultaneously with varying doses of anti-tuberculous sera derived from chicken, in order to examine the effects of antigen-antibody reaction between the bacilli and antituberculous sera upon survival time of the chick embryos. Thus, the relationship between allergy and immunity in tuberculosis was analysed from a simplified viewpoint of quantitative relation between antigen and antibody, inasmuch as secondary production of humoral or sessile antibodies may be ignored in chick embryo. The results indicated that the survival time of chick embryos was proportional to the quantity of tubercle bacilli injected, when normal chicken sera were injected into yolk sacs simultaneously with the infection, namely, the larger the quantity of bacilli, the shorter the survival time. The survival time of infected chick embryos was lengthened, when larger doses of anti-tuberculous sera were injected into yolk sacs. Anti-tuberculous sere in this case are considered to show a "favourable" effect upon embryo (immunity). The survival time of infected chick embryos was markedly shortened, when smaller or moderate doses of anti-tuberculous sera were injected into yolk sacs. Anti-tuberculous sera in this case are considered to show an "unfavourable" effect upon embryo (allergy). From the results mentioned above, the relationship between allergy and immunity in tuberculosis were discussed.
- 一般社団法人日本アレルギー学会の論文
- 1960-06-01