ラット下歯槽神経切断後の神経の回復過程 : 定量形態学的およびHRP神経標識法による検索

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To evaluate the general recovery process of sensory neural tracts of the inferior alveolar nerve, temporal changes in the recovery were histologically examined on rat at 3, 7, 14, 28, 42, 70 and 91 days after the nerve cutting. The scission of the nerve in the buccal cortical bone of a mandibula was made on an eight-week-old Wistar rat by a disk cutter. The results are as follows. 1. The nerve degeneration occurred by degrees until 14 days after nerve injury, in which myelin sheaths were flat compared with the control (the intact contralateral nerve), and the number of axons decreased. Few HRP-labeled cells within the Gasserian ganglion were observed. 2. At twenty-eight days after the nerve scission, morphological recovery of myelin sheaths were evident with a tendency for axons to become more hypertrophied. In addition, more HRP-labeled cells in the ganglion tended to be observed, which suggest that antidromic transport of HRP in the cutting portion occured. After 42 days, the experimental group exhibited about one and a half times the number of axons as the control. On the other hand, the number of HRP-labeled cells were half compared with that of the control. 3. At ninety-one days after nerve cutting, axon densities and their appearance in both experimental and control groups were very similar, and the numbers of axons were about one point three times higher than the control. The numbers of HRP-labeled cells in the ganglion had not changed from those observed at 42 days. In conclusion, these results suggest that the regeneration of the inferior alveolar nerve occurred within 91 days after the nerve scission in the rat.
奥羽大学の論文

著者

林由季
奥羽大学大学院歯学研究科顎口腔外科学専攻

ラット下歯槽神経切断後の神経の回復過程 : 定量形態学的およびHRP神経標識法による検索

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