Pathogen Burden in Essential Hypertension
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概要
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Background Associations between pathogens and hypertension (HT) has been reported, but few studies have focused on the relationship between aggregate pathogens and HT. The present study explored whether the risk of HT is associated with each pathogen (defined as Chlamydia pneumoniae (C. pneumoniaee), Mycoplasma pneumoniae (M. pneumoniae), Helicobacter pylori (H. pylori) and Coxsackie virus) or with aggregate pathogens in Chinese Mongolians. Methods and Results One thousand and thirty Chinese Mongolians aged 30 years or more were recruited, including 488 hypertensive and 942 normotensive subjects. Enzyme-linked immunosorbent assay was used to detect IgG antibodies for C. pneumoniaee, M. pneumoniae, H. pylori and Coxsackie virus. The seroprevalence of Coxsackie virus was significantly associated with HT (odds ratio (OR) 3.7 after adjustment for risk factors), but no significant association was found for C. pneumoniae, M. pneumoniae and H. pylori (OR 1.32, 0.75 and 1.19, respectively). The results also showed that the risk of HT was associated with the aggregate pathogens: it increased with the increasing number of pathogens, and the ORs were 1.629, 2.653, 2.129, and 5.146 for 1, 2, 3 and 4 pathogens, respectively, after controlling for risk factors. Conclusion The risk of HT is associated with Coxsackie virus and aggregate pathogen load. The mechanism(s) underlying the associations remain to be elucidated further. (Circ J 2007; 71: 1761-1764)
- 社団法人日本循環器学会の論文
- 2007-10-20
著者
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Liu Yanbin
Department Of Epidemiology Soochow University School Of Radiation Medicine And Public Health
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Liu Yanbin
Epidemiology Department School Of Radiation Medicine And Public Health Soochow University
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Tong Weijun
Department Of Epidemiology School Of Radiation Medicine And Public Health Medical College Of Soochow
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Tong Weijun
Epidemiology Department School Of Radiation Medicine And Public Health Soochow University
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Zhang Yonghong
Department Of Epidemiology School Of Radiation Medicine And Public Health Medical College Of Soochow
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Zhang Yonghong
Epidemiology Department School Of Radiation Medicine And Public Health Soochow University
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Zhang Xianyu
Department Of Epidemiology Naiman Qi Center For Disease Prevention And Control
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Zhang Xianyu
Epidemiology Department Center For Disease Prevention And Control Of Naiman Banner
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Liu Lijuan
State Key Laboratory Of Pathogen And Biosecurity Beijing Institute Of Microbiology And Epidemiology:
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Liu Lijuan
State Key Laboratory Of Pathogen And Biosecurity Beijing Institute Of Microbiology And Epidemiology
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Ye Hong
Department of Epidemiology, Public Health College, Harbin Medical University
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Cao Wuchun
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
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Ye Hong
Department Of Epidemiology Public Health College Harbin Medical University
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Cao Wuchun
State Key Laboratory Of Pathogen And Biosecurity Beijing Institute Of Microbiology And Epidemiology
関連論文
- Comparison of Cardiovascular Risk Factors Between Prehypertension and Hypertension in a Mongolian Population, Inner Mongolia, China
- Relationship of C-Reactive Protein With Hypertension and Interactions Between Increased C-Reactive Protein and Other Risk Factors on Hypertension in Mongolian People, China
- Prehypertension and Cardiovascular Risk Factor Clustering Among Mongolian Population in Rural and Animal Husbandry Area, Inner Mongolia, China
- Pathogen Burden in Essential Hypertension
- Co-effect of insulin resistance and biomarkers of inflammation and endothelial dysfunction on hypertension
- Association of elevated inflammatory and endothelial biomarkers with prehypertension among Mongolians in China