Effect of Sodium Nitroprusside on Amylase Secretion from Dispersed Rat Pancreatic Acini

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概要

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• To clarify the direct action of nitric oxide (NO) on pancreatic exocrine, the effect of sodium nitroprusside (SNP), an NO donor, on pancreatic amylase secretion was investigated in the dispersed pancreatic acini of rats. Although SNP failed to stimulate the secretion of amylase, SNP (3 mmol/L) conbined with carbachol (3 µmol/L) or with CCK-8 (30 nmol/L) approximately doubled amylase secretion over that induced by either carbachol or CCK-8 alone. SNP also elevated the level of cyclic guanosine 3',5'-monophosphate (cGMP) to a much greater extent than either carbachol or CCK-8. Pretreatment of SNP elevated intracellular calcium ion concentration ([Ca2+]i) both at rest and in the stimulated condition induced by carbachol or CCK-8. These findings suggest that SNP may promote the secretion of amylase stimulated by carbachol or CCK-8 through the elevation of cGMP and [Ca2+]i.

• 鳥取大学の論文

著者

• Ishimura Masahiko

  Department Of Clinical Phamacology And First Department Of Internal Medicine Faculty Of Medicine Tot

関連論文

• Effect of Sodium Nitroprusside on Amylase Secretion from Dispersed Rat Pancreatic Acini

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