New Entry for Synthesis of N-Acylhydrazones, Pyridazinones, and 1, 3, 4-Oxadiazin-6-ones from α-Amino Acid Esters

スポンサーリンク

概要

• 論文の詳細を見る

• Versatile electrophiles N-acylhydrazones are synthesized via diazotization, reduction, and acylation of α-amino acid esters. Reduction of diazo esters with L-selectride^[○!R]R or tributylphosphine affords the corresponding hydrazones in good yields. Both reducing agents give anti-hydrazones as the major product although the reactivity of each reductant is slightly different. The resulting hydrazones are acylated to give N-acylhydrazones, which are subjected to further reactions to give 1, 3, 4-oxadiazin-6-ones that serve as useful synthetic intermediates for the Diels-Alder reaction.

• 社団法人日本薬学会の論文
• 2007-11-01

著者

• Yasui Eiko

  Department Of Pharmaceutical Science Musashino University

• WADA Masao

  Department of Pharmaceutical Science, Musashino University

• TAKAMURA Norio

  Department of Pharmaceutical Science, Musashino University

• Takamura Norio

  Department Of Pharmaceutical Science Musashino University

• Wada Masao

  Department Of Pharmaceutical Science Musashino University

• Yasui Eiko

  Department of Applied Chemistry, Kogakuin University

• Wada Masao

  Department of Applied Chemistry, Faculty of Engineering, Keio University

関連論文

• New Entry for Synthesis of N-Acylhydrazones, Pyridazinones, and 1, 3, 4-Oxadiazin-6-ones from α-Amino Acid Esters
• Synthetic Studies of the Lichen Macrolide Lepranthin. Stereoselective Synthesis of the Diolide Framework Based on Regioselective Epoxide-Opening Reactions
• Total Syntheses of Antimycin A3 and Its Diastereomer

スポンサーリンク